Belotero is one of the newer choices in soft tissue fillers that was approved by the FDA in 2012. The hyaluronic acid-based formula works in similar fashion to other injectable fillers like Juvederm and Restylane to smooth away wrinkles from underneath the skin’s surface. However, Belotero offers a smoother, softer formula that makes it a good choice for finer facial lines and more delicate areas like under the eyes and around the mouth.